Endothelial cell apoptosis in chronically obstructed and reperfused pulmonary artery

@article{Sage2008EndothelialCA,
  title={Endothelial cell apoptosis in chronically obstructed and reperfused pulmonary artery},
  author={Edouard Sage and O. Ripeka Mercier and Frederic Van den Eyden and Marc E de Perrot and Anne Marie Barlier-Mur and Philippe G Dartevelle and Saadia Eddahibi and Philippe J. L. Herve and {\'E}lie Fadel},
  journal={Respiratory Research},
  year={2008},
  volume={9},
  pages={19 - 19}
}
BACKGROUND Endothelial dysfunction is a major complication of pulmonary endarterectomy (PTE) that can lead to pulmonary edema and persistent pulmonary hypertension. We hypothesized that endothelial dysfunction is related to increased endothelial-cell (EC) death. METHODS In piglets, the left pulmonary artery (PA) was ligated to induce lung ischemia then reimplanted into the main PA to reperfuse the lung. Animals sacrificed 5 weeks after ligation (n = 5), 2 days after reperfusion (n = 5), or 5… CONTINUE READING
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