Endothelial cell antibodies associated with novel targets and increased rejection.

Abstract

The initial contact point between a recipient's immune system and a transplanted graft is the vascular endothelium. Clinical studies suggest a pathogenic role for non-HLA antiendothelial cell antibodies (AECAs) in allograft rejection; however, evidence linking AECAs of known specificity to in vivo vascular injury is lacking. Here, we used high-density… (More)
DOI: 10.1681/ASN.2013121277

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