Endothelial cell activation and neovascularization are prominent in dermatomyositis

  title={Endothelial cell activation and neovascularization are prominent in dermatomyositis},
  author={Kanneboyina Nagaraju and Lisa G. Rider and Chenguang Fan and Yi-Wen Chen and Megan J Mitsak and Rashmi Rawat and Kathleen Patterson and Cecilia Grundtman and Frederick W Miller and Paul H. Plotz and Eric P. Hoffman and Ingrid E Lundberg},
  journal={Journal of Autoimmune Diseases},
  pages={2 - 2}
BACKGROUND While vascular and immune abnormalities are common in juvenile and adult dermatomyositis (DM), the molecular changes that contribute to these abnormalities are not clear. Therefore, we investigated pathways that facilitate new blood vessel formation and dendritic cell migration in dermatomyositis. METHODS Muscle biopsies from subjects with DM (9 children and 6 adults) and non-myositis controls (6 children and 7 adults) were investigated by immunohistochemistry using antibodies that… CONTINUE READING


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