Endothelial beta1 integrins regulate sprouting and network formation during vascular development.

Abstract

beta1 integrins are important regulators of vascular differentiation and development, as their endothelial-specific deletion results in embryonic lethality. In the present study, we investigated the molecular mechanisms underlying the prominent vascular abnormalities that occur in the absence of beta1 integrins. Because of the early embryonic lethality of… (More)
DOI: 10.1242/dev.045377