Endothelial barrier function in preeclampsia.

@article{Wang2007EndothelialBF,
  title={Endothelial barrier function in preeclampsia.},
  author={Yuping Wang and David F. Lewis and J S Alexander and Daniel Neil Granger},
  journal={Frontiers in bioscience : a journal and virtual library},
  year={2007},
  volume={12},
  pages={
          2412-24
        }
}
Impaired endothelial barrier function resulting in increased vascular permeability is a characteristic vascular response in preeclampsia, a hypertensive and multiple systemic disorder of human pregnancy. During the last two decades, endothelial function in preeclampsia has been intensively studied and significant progress has been made in understanding the cellular and molecular bases of the altered endothelial cell response. In this review, we address the nature and mechanisms that are… 
View on PubMed
bioscience.org
29 Citations
Background Citations
10
Methods Citations
1

29 Citations

Citation Type

Citation Type

Review: novel insights into the regulation of vascular tone by sphingosine 1-phosphate.
Vascular Dysfunction in Preeclampsia
TLDR
A detailed overview of vascular defects present during preeclampsia is provided and well-established notions to newer discoveries at the molecular, cellular, and whole-organism levels are connected.
Blood cells and endothelial barrier function
TLDR
The role of blood borne cells, including, neutrophils, lymphocytes, monocytes, and platelets, in the regulation of endothelial barrier function in health and disease is addressed.
Pericytes Contribute to Dysfunction in a Human 3D Model of Placental Microvasculature through VEGF‐Ang‐Tie2 Signaling
TLDR
A perfusable triculture model, consisting of human endothelial cells, fibroblasts, and pericytes, capable of recapitulating growth and remodeling in a system that mimics inflamed placental microvessels, highlights that an imbalance in endothelial–pericyte crosstalk can play a critical role in the development of vascular pathology and associated diseases.
Role of corin and atrial natriuretic peptide in preeclampsia.
Noninvasive Measurement of Retinal Microvascular Permeability During Loss of Endothelial Quiescence.
TLDR
A novel imaging methodology combining sodium fluorescein fundus angiography (FFA) with mathematical quantification allowing retinal permeability to be noninvasively and accurately measured at multiple time points in the same animal, minimizing animal use in line with the 3Rs framework is described.
Hypoxic Trophoblast HMGB1 Induces Endothelial Cell Hyperpermeability via the TRL-4/Caveolin-1 Pathway
TLDR
It is concluded that hypoxic trophoblasts play an important role in the mechanism of general edema in PE via increasing endothelial monolayer permeability through the HMGB1/TLR4/CAV-1 pathway.
Altered expressions of endothelial junction protein of placental capillaries in premature infants with intraventricular hemorrhage
TLDR
Hypoxia altered expression of endothelial junction protein in placental capillaries was evaluated and its correlation with the incidence of intraventricular hemorrhage in premature infants was observed.
PAR-2 triggers placenta-derived protease-induced altered VE-cadherin reorganization at endothelial junctions in preeclampsia.
Nicotine Suppresses Interleukin-6 Production From Vascular Endothelial Cells: A Possible Therapeutic Role of Nicotine for Preeclampsia
TLDR
Nicotine inhibited inflammatory reaction through NF-kB suppression in vitro model of maternal vascular endothelium, and this effect may be one of the explanations for the reduced risk of preeclampsia in smokers.
...
1
2
3
...

References

SHOWING 1-10 OF 118 REFERENCES
Placental pathophysiology in preeclampsia
Placental trophoblast-derived factors diminish endothelial barrier function.
TLDR
It is concluded that placental trophoblast cells produce factors that diminish the barrier function of endothelial cells and endothelial tight junctions are more susceptible to factors released from preeclamptic trophoplast cells than from normal trophOBlast cells, which implicate troPHoblast-derived factors in the increased vascular permeability associated with preeclampsia.
The Effects of Preeclampsia and Oxygen Environment on Endothelial Release of Matrix Metalloproteinase‐2
TLDR
Preeclamptic endothelial cells demonstrate significantly enhanced MMP‐2, TIMP‐1 and TIMP-2 release compared to normal cells; however, the magnitude of the enhanced release is small when compared to the differences in M MP‐2 release in cells from preeClamptic and normal pregnancies.
Preeclampsia: an endothelial cell disorder.
Vascular endothelial growth factor induced functional and morphologic signs of endothelial dysfunction in isolated arteries from normal pregnant women.
TLDR
Vascular endothelial growth factor impaired bradykinin-mediated dilatation and enhanced basal tone and permeability, which might indicate a potential role for vascular endothelial grow factor in the development of endothelial dysfunction in pregnancy.
Elevated Serum Levels of Vascular Endothelial Growth Factor in Patients With Preeclampsia
Endothelial junctional protein redistribution and increased monolayer permeability in human umbilical vein endothelial cells isolated during preeclampsia.
TLDR
The altered endothelial cell junctional protein distribution and expression of vascular endothelial cadherin and occludin observed in the first passage of endothelial cells from preeclampsia was restored to normal by the time cells reached the third passage in vitro.
Evidence for peroxynitrite formation in the vasculature of women with preeclampsia.
TLDR
Data of increased endothelial NO synthase, decreased SOD, and increased nitrotyrosine immunostaining in the maternal vasculature of women with preeclampsia suggest increased peroxynitrite formation, which is speculated to contribute to the pathophysiology of this pregnancy disorder.
Evidence of endothelial dysfunction in preeclampsia: decreased endothelial nitric oxide synthase expression is associated with increased cell permeability in endothelial cells from preeclampsia.
Increased Superoxide Generation and Decreased Stress Protein Hsp90 Expression in Human Umbilical Cord Vein Endothelial Cells (HUVECs) from Pregnancies Complicated by Preeclampsia
TLDR
These in vitro HUVEC data suggest that increased endothelial oxidative stress may also occur in the fetal compartment during preeclampsia.
...
1
2
3
4
5
...