Endothelial barrier dysfunction caused by LPS correlates with phosphorylation of HSP27in vivo

@article{Hirano2004EndothelialBD,
  title={Endothelial barrier dysfunction caused by LPS correlates with phosphorylation of HSP27in vivo},
  author={Seishiro Hirano and Riley S. Rees and Shannon L Yancy and Michael J. Welsh and Daniel G Remick and Tetsuya Yamada and Junichi Hata and Robert R. Gilmont},
  journal={Cell Biology and Toxicology},
  year={2004},
  volume={20},
  pages={1-14}
}
Lung edema during sepsis is triggered by formation of gaps between endothelial cells followed by macrophage infiltration. Endothelial gap formation has been proposed to involve changes in the structure of the actin filament cytoskeleton. Heat shock protein 27 (HSP27) is believed to modulate actin filament dynamics or structure, in a manner dependent on its phosphorylation status. We hypothesized that HSP27 may play a role in endothelial gap formation, by affecting actin dependent events in… CONTINUE READING

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