Endothelial autophagy and Endothelial-to-Mesenchymal Transition (EndoMT) in eEPC treatment of ischemic AKI

@inproceedings{Patschan2016EndothelialAA,
  title={Endothelial autophagy and Endothelial-to-Mesenchymal Transition (EndoMT) in eEPC treatment of ischemic AKI},
  author={D Patschan and Katrin Schwarze and Elvira Henze and Susann A Patschan and Gerhard A. M{\"u}ller},
  booktitle={Journal of nephrology},
  year={2016}
}
BACKGROUND Autophagy enables cells to digest endogenous/exogenous waste products, thus potentially prolonging the cellular lifespan. Early endothelial progenitor cells (eEPCs) protect mice from ischemic acute kidney injury (AKI). The mid-term prognosis in AKI critically depends on vascular rarefication and interstitial fibrosis with the latter partly being induced by mesenchymal transdifferentiation of endothelial cells (EndoMT). This study aimed to determine the impact of eEPC preconditioning… CONTINUE READING
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