Endothelial apoptosis initiates acute blood-brain barrier disruption after ionizing radiation.

@article{Li2003EndothelialAI,
  title={Endothelial apoptosis initiates acute blood-brain barrier disruption after ionizing radiation.},
  author={Yu-qing Li and Paul F-T Chen and Adriana Haimovitz-Friedman and Raymond M Reilly and Carolyn Wong},
  journal={Cancer research},
  year={2003},
  volume={63 18},
  pages={5950-6}
}
Acute disruption of blood-brain barrier (BBB) is well recognized after radiation therapy to the central nervous system (CNS). We assessed the genetic regulation of acute BBB disruption and its relationship to vascular endothelial cell death in the CNS after irradiation. Adult rats were given graded single doses of X-ray to the cervical spinal cord. At different time intervals after irradiation, the irradiated spinal cord was processed for histological and immunohistochemical analysis… CONTINUE READING