Endothelial apoptosis and chronic transplant vasculopathy: recent results, novel mechanisms.

@article{Cailhier2006EndothelialAA,
  title={Endothelial apoptosis and chronic transplant vasculopathy: recent results, novel mechanisms.},
  author={J Cailhier and Patrick Laplante and M J H{\'e}bert},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2006},
  volume={6 2},
  pages={247-53}
}
Chronic transplant vasculopathy (CTV) is a progressive form of vascular obliteration affecting the arteries, arterioles and capillaries of solid organ transplants. It is characterized by intimal accumulation of mononuclear cells, vascular smooth muscle cells (VSMC), myofibroblasts and connective tissue. Mounting evidence, based on animal models and human biopsy results, suggests that acute and persistent rejection triggering apoptosis of endothelial cells (EC) plays a pivotal role in CTV. The… CONTINUE READING

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