Endothelial alterations in hypercholesterolemia: more than simply vasodilator dysfunction.

@article{Tsao1998EndothelialAI,
  title={Endothelial alterations in hypercholesterolemia: more than simply vasodilator dysfunction.},
  author={Philip S. Tsao and John P Cooke},
  journal={Journal of cardiovascular pharmacology},
  year={1998},
  volume={32 Suppl 3},
  pages={S48-53}
}
Occlusive vascular disease begins with an alteration of the endothelium, which is characterized by a decrease in nitric oxide (NO) activity. Endogenous NO inhibits many key processes in atherogenesis, including monocyte adherence, platelet activation, and smooth muscle proliferation. The mechanism by which NO activity is reduced in hypercholesterolemia and in other metabolic disorders associated with atherogenesis appears to be multifactorial. It includes increased production of oxygen-derived… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

Similar Papers

Loading similar papers…