Endothelial activation during interleukin 2 immunotherapy. A possible mechanism for the vascular leak syndrome.

@article{Cotran1988EndothelialAD,
  title={Endothelial activation during interleukin 2 immunotherapy. A possible mechanism for the vascular leak syndrome.},
  author={Ramzi S. Cotran and Jordan S Pober and Michael A. Gimbrone and Timothy A Springer and Eric A. Wiebke and Anthony A. Gaspari and Steven A Rosenberg and Michael T Lotze},
  journal={Journal of immunology},
  year={1988},
  volume={140 6},
  pages={1883-8}
}
A major sequela of immunotherapy with interleukin 2 (IL-2) is development of a vascular leak syndrome. The pathogenesis of this toxic effect is not known. We have examined pre- and post-treatment skin biopsies from 14 patients undergoing systemic administration of IL-2 for evidence of endothelial cell activation. Specifically, we have used the immunoperoxidase technique to detect the expression of three different activation antigens: endothelial-leukocyte adhesion molecule 1, detected with… CONTINUE READING
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