Endothelial actions of atrial and B-type natriuretic peptides.

  title={Endothelial actions of atrial and B-type natriuretic peptides.},
  author={Michaela Kuhn},
  journal={British journal of pharmacology},
  volume={166 2},
The cardiac hormone atrial natriuretic peptide (ANP) is critically involved in the maintenance of arterial blood pressure and intravascular volume homeostasis. Its cGMP-producing GC-A receptor is densely expressed in the microvascular endothelium of the lung and systemic circulation, but the functional relevance is controversial. Some studies reported that ANP stimulates endothelial cell permeability, whereas others described that the peptide attenuates endothelial barrier dysfunction provoked… CONTINUE READING
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