Endothelial actin cytoskeleton remodeling during mechanostimulation with fluid shear stress.

  title={Endothelial actin cytoskeleton remodeling during mechanostimulation with fluid shear stress.},
  author={Eric A. Osborn and Aleksandr Rabodzey and C. Forbes Dewey and John H. Hartwig},
  journal={American journal of physiology. Cell physiology},
  volume={290 2},
Fluid shear stress stimulation induces endothelial cells to elongate and align in the direction of applied flow. Using the complementary techniques of photoactivation of fluorescence and fluorescence recovery after photobleaching, we have characterized endothelial actin cytoskeleton dynamics during the alignment process in response to steady laminar fluid flow and have correlated these results to motility. Alignment requires 24 h of exposure to fluid flow, but the cells respond within minutes… CONTINUE READING
46 Citations
41 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 46 extracted citations


Publications referenced by this paper.
Showing 1-10 of 41 references

Simultaneous measurements of actin filament turnover, filament fraction, and monomer diffusion in endothelial cells

  • JL McGrath, Y Tardy, CF JrDewey, JJ Meister, JH. Hartwig
  • Biophys J
  • 1998
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…