Endothelial Tip Cells in Ocular Angiogenesis

@inproceedings{Siemerink2013EndothelialTC,
  title={Endothelial Tip Cells in Ocular Angiogenesis},
  author={Martin J. Siemerink and Ingeborg Klaassen and Cornelis J. F. van Noorden and Reinier O. Schlingemann},
  booktitle={The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society},
  year={2013}
}
Endothelial tip cells are leading cells at the tips of vascular sprouts coordinating multiple processes during angiogenesis. In the developing retina, tip cells play a tightly controlled, timely role in angiogenesis. In contrast, excessive numbers of tip cells are a characteristic of the chaotic pathological blood vessels in proliferative retinopathies. Tip cells control adjacent endothelial cells in a hierarchical manner to form the stalk of the sprouting vessel, using, among others, the VEGF… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 106 REFERENCES

MicroRNAs regulate ocular neovascularization.

  • Molecular therapy : the journal of the American Society of Gene Therapy
  • 2008
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Blood vessels and nerves: common signals, pathways and diseases

  • Nature Reviews Genetics
  • 2003
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL