Endothelial Senescence Contributes to Heart Failure With Preserved Ejection Fraction in an Aging Mouse Model

@article{Gevaert2017EndothelialSC,
  title={Endothelial Senescence Contributes to Heart Failure With Preserved Ejection Fraction in an Aging Mouse Model},
  author={Andreas B Gevaert and Hadis Shakeri and Arthur J.A. Leloup and Cor E. Van Hove and Guido R. Y. De Meyer and Christiaan J M Vrints and Katrien Lemmens and Emeline M. Van Craenenbroeck},
  journal={Circulation: Heart Failure},
  year={2017},
  volume={10},
  pages={e003806}
}
Background— Because of global aging, the prevalence of heart failure with preserved ejection fraction (HFpEF) continues to rise. Although HFpEF pathophysiology remains incompletely understood, endothelial inflammation is stated to play a central role. Cellular senescence is a process of cellular growth arrest linked with aging and inflammation. We used mice with accelerated aging to investigate the role of cellular senescence in HFpEF development. Methods and Results— Senescence-accelerated… 

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