Endothelial Senescence Contributes to Heart Failure With Preserved Ejection Fraction in an Aging Mouse Model.

@article{Gevaert2017EndothelialSC,
  title={Endothelial Senescence Contributes to Heart Failure With Preserved Ejection Fraction in an Aging Mouse Model.},
  author={Andreas B Gevaert and Hadis Shakeri and Arthur J. A. Leloup and Cor E. Van Hove and Guido R Y De Meyer and Christiaan J M Vrints and Katrien Lemmens and Emeline M Van Craenenbroeck},
  journal={Circulation. Heart failure},
  year={2017},
  volume={10 6}
}
BACKGROUND Because of global aging, the prevalence of heart failure with preserved ejection fraction (HFpEF) continues to rise. Although HFpEF pathophysiology remains incompletely understood, endothelial inflammation is stated to play a central role. Cellular senescence is a process of cellular growth arrest linked with aging and inflammation. We used mice with accelerated aging to investigate the role of cellular senescence in HFpEF development. METHODS AND RESULTS Senescence-accelerated… CONTINUE READING
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