Endothelial Progenitor Cells Control the Angiogenic Switch in Mouse Lung Metastasis

@article{Gao2008EndothelialPC,
  title={Endothelial Progenitor Cells Control the Angiogenic Switch in Mouse Lung Metastasis},
  author={Dingcheng Gao and Daniel J. Nolan and Albert S. Mellick and Kathryn Bambino and Kevin A. Mcdonnell and Vivek Mittal},
  journal={Science},
  year={2008},
  volume={319},
  pages={195 - 198}
}
Angiogenesis-mediated progression of micrometastasis to lethal macrometastasis is the major cause of death in cancer patients. Here, using mouse models of pulmonary metastasis, we identify bone marrow (BM)–derived endothelial progenitor cells (EPCs) as critical regulators of this angiogenic switch. We show that tumors induce expression of the transcription factor Id1 in the EPCs and that suppression of Id1 after metastatic colonization blocked EPC mobilization, caused angiogenesis inhibition… 
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CXCR2-Dependent Endothelial Progenitor Cell Mobilization in Pancreatic Cancer Growth.
TLDR
It is reported that the mobilization of bone marrow-derived endothelial progenitor cells (EPCs) is impaired in CXCR2 knockout mice harboring pancreatic cancers, which indicates a role of BM-derived EPC in pancreatic cancer growth and provides a cellular mechanism for CX CR2 mediated tumor neovascularization.
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TLDR
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