Endothelial Progenitor Cells Control the Angiogenic Switch in Mouse Lung Metastasis

@article{Gao2008EndothelialPC,
  title={Endothelial Progenitor Cells Control the Angiogenic Switch in Mouse Lung Metastasis},
  author={Dingcheng Gao and D. Nolan and A. Mellick and Kathryn Bambino and K. Mcdonnell and V. Mittal},
  journal={Science},
  year={2008},
  volume={319},
  pages={195 - 198}
}
Angiogenesis-mediated progression of micrometastasis to lethal macrometastasis is the major cause of death in cancer patients. Here, using mouse models of pulmonary metastasis, we identify bone marrow (BM)–derived endothelial progenitor cells (EPCs) as critical regulators of this angiogenic switch. We show that tumors induce expression of the transcription factor Id1 in the EPCs and that suppression of Id1 after metastatic colonization blocked EPC mobilization, caused angiogenesis inhibition… Expand
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References

SHOWING 1-10 OF 20 REFERENCES
A homing mechanism for bone marrow-derived progenitor cell recruitment to the neovasculature.
...
1
2
...