Endothelial Progenitor Cell Fraction Contained in Bone Marrow-Derived Mesenchymal Stem Cell Populations Impairs Osteogenic Differentiation

@inproceedings{Duttenhoefer2015EndothelialPC,
  title={Endothelial Progenitor Cell Fraction Contained in Bone Marrow-Derived Mesenchymal Stem Cell Populations Impairs Osteogenic Differentiation},
  author={Fabian Duttenhoefer and Rafael Lara de Freitas and Markus Loibl and G. Bittermann and R Geoff Richards and Mauro Alini and Sophie Verrier},
  booktitle={BioMed research international},
  year={2015}
}
In bone tissue engineering (TE) endothelial cell-osteoblast cocultures are known to induce synergies of cell differentiation and activity. Bone marrow mononucleated cells (BMCs) are a rich source of mesenchymal stem cells (MSCs) able to develop an osteogenic phenotype. Endothelial progenitor cells (EPCs) are also present within BMC. In this study we investigate the effect of EPCs present in the BMC population on MSCs osteogenic differentiation. Human BMCs were isolated and separated into two… CONTINUE READING