Endothelial P2-purinoceptors: subtypes and signal transduction.

  title={Endothelial P2-purinoceptors: subtypes and signal transduction.},
  author={Sabine Pirotton and Didier Communi and Sophie Motte and Roel Janssens and J. M. Boeynaems},
  journal={Journal of autonomic pharmacology},
  volume={16 6},
1. Adenine nucleotides stimulate the synthesis and release of prostacyclin and nitric oxide (two potent platelet aggregation inhibitors) by endothelial cells from different origins. These responses are mediated by P2 purinergic receptors, coupled to the production of inositol (1,4,5)trisphosphate (InsP3) and to the increase of intracytoplasmic calcium concentration. 2. In bovine aortic endothelial cells (BAEC), both 2-MeSATP and UTP stimulate the production of InsP3. By experiments of… CONTINUE READING


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