Endothelial Nitric Oxide Mediates Caffeine Antagonism of Alcohol-Induced Cerebral Artery Constriction

@article{Chang2016EndothelialNO,
  title={Endothelial Nitric Oxide Mediates Caffeine Antagonism of Alcohol-Induced Cerebral Artery Constriction},
  author={Jennifer Chang and A. Fedinec and G. Kuntamallappanavar and C. Leffler and A. Bukiya and A. Dopico},
  journal={The Journal of Pharmacology and Experimental Therapeutics},
  year={2016},
  volume={356},
  pages={106 - 115}
}
Despite preventive education, the combined consumption of alcohol and caffeine (particularly from “energy drinks”) continues to rise. Physiologic perturbations by separate intake of ethanol and caffeine have been widely documented. However, the biologic actions of the alcohol-caffeine combination and their underlying subcellular mechanisms have been scarcely studied. Using intravital microscopy on a closed-cranial window and isolated, pressurized vessels, we investigated the in vivo and in… Expand
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