Endothelial NADPH oxidase: mechanism of activation by low-density lipoprotein.

  title={Endothelial NADPH oxidase: mechanism of activation by low-density lipoprotein.},
  author={Robert W. O'Donnell and David K Johnson and Linda M Ziegler and Andrew J DiMattina and Robert I Stone and James A. Holland},
  journal={Endothelium : journal of endothelial cell research},
  volume={10 6},
Exposure to atherogenic levels of low-density lipoprotein (LDL) causes elevated reactive oxygen species (ROS) production by human endothelial cells (ECs). NADPH oxidase is thought to be the main source of ROS generated by LDL-activated ECs. The mechanism by which this lipoprotein activates endothelial NADPH oxidase is incompletely understood. To gain further insight into the signaling pathway, the authors have examined the effects of inhibitors to various signal transducing enzymes, including… CONTINUE READING