Endothelial Mineralocorticoid Receptor Mediates Diet-Induced Aortic Stiffness in Females.

@article{Jia2016EndothelialMR,
  title={Endothelial Mineralocorticoid Receptor Mediates Diet-Induced Aortic Stiffness in Females.},
  author={Guanghong Jia and Javad Habibi and Annayya R. Aroor and Luis A. Martinez-Lemus and Vincent G DeMarco and Francisco I. Ramirez-Perez and Zhe Sun and Melvin R. Hayden and Gerald A. Meininger and Katelee Barrett Mueller and Iris Z Jaffe and James R. Sowers},
  journal={Circulation research},
  year={2016},
  volume={118 6},
  pages={935-943}
}
RATIONALE Enhanced activation of the mineralocorticoid receptors (MRs) in cardiovascular tissues increases oxidative stress, maladaptive immune responses, and inflammation with associated functional vascular abnormalities. We previously demonstrated that consumption of a Western diet (WD) for 16 weeks results in aortic stiffening, and that these abnormalities were prevented by systemic MR blockade in female mice. However, the cell-specific role of endothelial cell MR (ECMR) in these maladaptive… CONTINUE READING
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