Endothelial Membrane Remodeling Is Obligate for Anti-Angiogenic Radiosensitization during Tumor Radiosurgery

@inproceedings{Truman2010EndothelialMR,
  title={Endothelial Membrane Remodeling Is Obligate for Anti-Angiogenic Radiosensitization during Tumor Radiosurgery},
  author={J. Kelly Truman and M{\'o}nica Garc{\'i}a-Barros and Matthew Kaag and D Hambardzumyan and Branka Stancevic and Michael Kam-tim Chan and Zvi Fuks and Richard N. Kolesnick and Adriana Haimovitz-Friedman},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND While there is significant interest in combining anti-angiogenesis therapy with conventional anti-cancer treatment, clinical trials have as of yet yielded limited therapeutic gain, mainly because mechanisms of anti-angiogenic therapy remain to a large extent unknown. Currently, anti-angiogenic tumor therapy is conceptualized to either "normalize" dysfunctional tumor vasculature, or to prevent recruitment of circulating endothelial precursors into the tumor. An alternative biology… CONTINUE READING

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