Endothelial Lineage Differentiation from Induced Pluripotent Stem Cells Is Regulated by MicroRNA-21 and Transforming Growth Factor β2 (TGF-β2) Pathways*

@inproceedings{Bernardini2014EndothelialLD,
  title={Endothelial Lineage Differentiation from Induced Pluripotent Stem Cells Is Regulated by MicroRNA-21 and Transforming Growth Factor β2 (TGF-β2) Pathways*},
  author={Elisabetta di Bernardini and Paola Campagnolo and Andriana Margariti and Anna Zampetaki and Eirini Karamariti and Yanhua Hu and Qingbo Xu},
  booktitle={The Journal of biological chemistry},
  year={2014}
}
Finding a suitable cell source for endothelial cells (ECs) for cardiovascular regeneration is a challenging issue for regenerative medicine. In this paper, we describe a novel mechanism regulating induced pluripotent stem cells (iPSC) differentiation into ECs, with a particular focus on miRNAs and their targets. We first established a protocol using collagen IV and VEGF to drive the functional differentiation of iPSCs into ECs and compared the miRNA signature of differentiated and… CONTINUE READING
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