Endothelial K(ca) channels mediate flow-dependent dilation of arterioles of skeletal muscle and mesentery.

@article{Sun2001EndothelialKC,
  title={Endothelial K(ca) channels mediate flow-dependent dilation of arterioles of skeletal muscle and mesentery.},
  author={Dong K. Sun and An Hua Huang and A. E. Koller and Gabor Kaley},
  journal={Microvascular research},
  year={2001},
  volume={61 2},
  pages={179-86}
}
The role of Ca(2+)-activated potassium channels (K(Ca)) in flow-initiated intracellular events in microvessels is not known. We hypothesized that K(Ca) channels in the arteriolar endothelium are responsible for the mechanotransduction of flow/shear stress-induced arteriolar dilation in skeletal muscle and mesentery of rats. The active diameter of arterioles isolated from gracilis (80 mm Hg) and cremaster (60 mm Hg) muscles and mesentery (80 mm Hg) at a constant intraluminal pressure was 53… CONTINUE READING

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