Endothelial Jagged1 antagonizes Dll4 regulation of endothelial branching and promotes vascular maturation downstream of Dll4/Notch1.

@article{Pedrosa2015EndothelialJA,
  title={Endothelial Jagged1 antagonizes Dll4 regulation of endothelial branching and promotes vascular maturation downstream of Dll4/Notch1.},
  author={Ana-Rita Pedrosa and Alexandre M F Trindade and Ana-Carina Fernandes and Catarina de Brito Carvalho and Joana Gigante and Ana Teresa Tavares and Rodrigo Di{\'e}guez-Hurtado and H. Yagita and Ralf H Adams and Ant{\'o}nio Duarte},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2015},
  volume={35 5},
  pages={1134-46}
}
OBJECTIVE Notch signaling controls cardiovascular development and has been associated with several pathological conditions. Among its ligands, Jagged1 and Dll4 were shown to have opposing effects in developmental angiogenesis, but the underlying mechanism and the role of Jagged1/Notch signaling in adult angiogenesis remain incompletely understood. The current study addresses the importance of endothelial Jagged1-mediated Notch signaling in the context of adult physiological angiogenesis and the… CONTINUE READING

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