Endothelial Glycocalyx: Permeability Barrier and Mechanosensor

  title={Endothelial Glycocalyx: Permeability Barrier and Mechanosensor},
  author={Fitz-Roy Curry and Roger H. Adamson},
  journal={Annals of Biomedical Engineering},
Endothelial cells are covered with a polysaccharide rich layer more than 400 nm thick, mechanical properties of which limit access of circulating plasma components to endothelial cell membranes. The barrier properties of this endothelial surface layer are deduced from the rate of tracer penetration into the layer and the mechanics of red and white cell movement through capillary microvessels. This review compares the mechanosensor and permeability properties of an inner layer (100–150 nm, close… CONTINUE READING


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