Endothelial Fli1 deficiency impairs vascular homeostasis: a role in scleroderma vasculopathy.

@article{Asano2010EndothelialFD,
  title={Endothelial Fli1 deficiency impairs vascular homeostasis: a role in scleroderma vasculopathy.},
  author={Yoshihide Asano and Lukasz Stawski and Faye N Hant and Kristin Highland and Richard I Silver and Gabor Szalai and Dennis K. Watson and Maria Trojanowska},
  journal={The American journal of pathology},
  year={2010},
  volume={176 4},
  pages={1983-98}
}
Systemic sclerosis or scleroderma (SSc) is a complex autoimmune connective tissue disease characterized by obliterative vasculopathy and tissue fibrosis. The molecular mechanisms underlying SSc vasculopathy are largely unknown. Friend leukemia integration factor 1 (Fli1), an important regulator of immune function and collagen fibrillogenesis, is expressed at reduced levels in endothelial cells in affected skin of patients with SSc. To develop a disease model and to investigate the function of… CONTINUE READING