Endothelial Dysfunction as a Target for Prevention of Cardiovascular Disease

@inproceedings{Versari2009EndothelialDA,
  title={Endothelial Dysfunction as a Target for Prevention of Cardiovascular Disease},
  author={Daniele Versari and Elena Daghini and Agostino Virdis and Lorenzo Ghiadoni and Stefano Taddei},
  booktitle={Diabetes care},
  year={2009}
}
The endothelium, once considered a mere selectively permeable barrier between the bloodstream and the outer vascular wall, is now recognized to be a crucial homeostatic organ, fundamental for the regulation of the vascular tone and structure. Indeed, endothelial cells are able to synthesize and secrete a broad spectrum of anti-atherosclerotic substances, the most characterized of which is nitric oxide (NO), a gas that is generated from the metabolism of L-arginine by endothelial NO synthase… CONTINUE READING