Endothelial Dysfunction: A Marker of Atherosclerotic Risk

@article{Bonetti2003EndothelialDA,
  title={Endothelial Dysfunction: A Marker of Atherosclerotic Risk},
  author={Piero O. Bonetti and Lilach Orly Lerman and Amir Lerman},
  journal={Arteriosclerosis, Thrombosis, and Vascular Biology: Journal of the American Heart Association},
  year={2003},
  volume={23},
  pages={168-175}
}
  • P. Bonetti, L. Lerman, A. Lerman
  • Published 1 February 2003
  • Medicine, Biology
  • Arteriosclerosis, Thrombosis, and Vascular Biology: Journal of the American Heart Association
Abstract—Endothelial dysfunction is a systemic disorder and a key variable in the pathogenesis of atherosclerosis and its complications. Current evidence suggests that endothelial status is not determined solely by the individual risk factor burden but rather, may be regarded as an integrated index of all atherogenic and atheroprotective factors present in an individual, including known as well as yet-unknown variables and genetic predisposition. Endothelial dysfunction reflects a vascular… 
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References

SHOWING 1-10 OF 94 REFERENCES
Hormone replacement therapy and endothelial function: the exception that proves the rule?
  • J. Vita, J. Keaney
  • Biology, Medicine
    Arteriosclerosis, thrombosis, and vascular biology
  • 2001
The endothelium plays a central role in the regulation of vascular homeostasis by releasing paracrine factors that influence vascular tone, thrombosis, and inflammation in the arterial wall.1 A
Prognostic Value of Coronary Vascular Endothelial Dysfunction
TLDR
Epicardial and microvascular coronary endothelial dysfunction independently predict acute cardiovascular events in patients with and without CAD, providing both functional and prognostic information that complements angiographic and risk factor assessment.
Oxidant stress as a marker for cardiovascular events: Ox marks the spot.
TLDR
During the past decade, numerous experimental and clinical studies have demonstrated that many common conditions predisposing to atherosclerosis, such as hypercholesterolemia, hypertension, diabetes, and smoking, are associated with a reduced vascular availability of nitric oxide, and endothelium-dependent vasodilation, a surrogate for NO• bioavailability, may predict cardiovascular events.
Prognostic significance of endothelial dysfunction in hypertensive patients.
TLDR
Endothelium-dependent and -independent vasodilation was investigated in 225 never-treated hypertensive patients by intra-arterial infusion of increasing doses of ACh and sodium nitroprusside by finding no significant differences between the groups.
Inflammation and Atherosclerosis
TLDR
New insights into inflammation in atherosclerosis not only increase the understanding of this disease, but also have practical clinical applications in risk stratification and targeting of therapy for this scourge of growing worldwide importance.
Endothelial Dysfunction, Oxidative Stress, and Risk of Cardiovascular Events in Patients With Coronary Artery Disease
TLDR
Data support the concept that oxidative stress may contribute not only to endothelial dysfunction but also to coronary artery disease activity, and predict the risk of cardiovascular events in patients with coronary arteries disease.
Estrogens, progestins, and heart disease: can endothelial function divine the benefit?
TLDR
It is concluded that the addition of a progestin in a hormone replacement regimen may counteract the beneficial effects of estrogen alone on cardiovascular disease, and endothelial function is not an appropriate intermediate biological outcome for assessing coronary heart disease therapy.
Endothelial dysfunction in coronary heart disease.
TLDR
Lowering the lipid or macrophage pools stored in the plaque may stabilize the plaque and reduce the risk for plaque rupture, and cholesterol-lowering trials have yielded a significant reduction in acute cardiac events.
...
1
2
3
4
5
...