Endothelial Cells in Co-culture Enhance Embryonic Stem Cell Differentiation to Pancreatic Progenitors and Insulin-Producing Cells through BMP Signaling

@inproceedings{TalaveraAdame2011EndothelialCI,
  title={Endothelial Cells in Co-culture Enhance Embryonic Stem Cell Differentiation to Pancreatic Progenitors and Insulin-Producing Cells through BMP Signaling},
  author={Dodanim Talavera-Adame and Gordon D. Wu and Yao He and Tina T. Ng and Ankur Gupta and Silvia Kurtovic and Jae Youn Hwang and Daniel L. Farkas and Donald C. Dafoe},
  booktitle={Stem Cell Reviews and Reports},
  year={2011}
}
Endothelial cells (ECs) represent the major component of the embryonic pancreatic niche and play a key role in the differentiation of insulin-producing β cells in vivo. However, it is unknown if ECs promote such differentiation in vitro. We investigated whether interaction of ECs with mouse embryoid bodies (EBs) in culture promotes differentiation of… CONTINUE READING