Endothelial Cell Sensitization by Death Receptor Fractions of an Anti-Dengue Nonstructural Protein 1 Antibody Induced Plasma Leakage, Coagulopathy, and Mortality in Mice.

@article{Sun2015EndothelialCS,
  title={Endothelial Cell Sensitization by Death Receptor Fractions of an Anti-Dengue Nonstructural Protein 1 Antibody Induced Plasma Leakage, Coagulopathy, and Mortality in Mice.},
  author={Der-Shan Sun and Ying-Chen Chang and Te-Sheng Lien and Chwan-Chuen King and Yung-Luen Shih and Hsuan-shun Huang and Teng-Yi Wang and Chen-Ru Li and C Lee and P N Hsu and Hsin-Hou Chang},
  journal={Journal of immunology},
  year={2015},
  volume={195 6},
  pages={2743-53}
}
The mechanisms leading to the life-threatening dengue hemorrhagic fever (DHF) remain elusive. DHF preferentially occurs during secondary dengue infections, suggesting that aberrant immune responses are involved in its development. We previously demonstrated that the autoantibodies elicited by dengue virus (DENV) nonstructural protein 1 (NS1; anti-NS1 Igs) induce plasma leakage and mortality in mice with warfarinized anticoagulant suppression. However, the involved pathogenic Ig fractions of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

Similar Papers

Loading similar papers…