Endothelial Cell-Selective Materials for Tissue Engineering in the Vascular Graft Via a New Receptor

@article{Hubbell1991EndothelialCM,
  title={Endothelial Cell-Selective Materials for Tissue Engineering in the Vascular Graft Via a New Receptor},
  author={Jeffrey A Hubbell and Stephen P. Massia and Neil P. Desai and Paul D. Drumheller},
  journal={Bio/Technology},
  year={1991},
  volume={9},
  pages={568-572}
}
We have found a novel adhesion receptor on the human endothelial cell for the peptide sequence Arg-Glu-Asp-Val (REDV), which is present in the III-CS domain of human plasma fibronectin, with a dissociation constant of 2.2 × 10−6 M and 5.8 × 106 sites/cell. When a synthetic peptide containing this sequence was immobilized on otherwise cell nonadhesive substrates, endothelial cells attached and spread but fibroblasts, vascular smooth muscle cells, and platelets did not. Endothelial mono-layers on… CONTINUE READING

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