Endothelial Cell HIF-1α and HIF-2α Differentially Regulate Metastatic Success

  title={Endothelial Cell HIF-1α and HIF-2α Differentially Regulate Metastatic Success},
  author={Cristina Branco-Price and Na Zhang and Moritz Schnelle and Colin Edward Evans and D{\"o}rthe Magdalena Katschinski and Debbie Liao and Lesley G Ellies and Randall S Johnson},
  booktitle={Cancer cell},
The hypoxia inducible transcription factors (HIFs) control many mediators of vascular response, including both angiogenic factors and small molecules such as nitric oxide (NO). In studying how endothelial HIF response itself affects metastasis, we found that loss of HIF-1α in endothelial cells reduces NO synthesis, retards tumor cell migration through endothelial layers, and restricts tumor cell metastasis, and that loss of HIF-2α has in each case the opposite effect. This results from… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 45 times over the past 90 days. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 68 extracted citations


Publications referenced by this paper.
Showing 1-10 of 72 references

Similar Papers

Loading similar papers…