Endothelial Akt signaling is rate-limiting for rapamycin inhibition of mouse mammary tumor progression.

@article{Phung2007EndothelialAS,
  title={Endothelial Akt signaling is rate-limiting for rapamycin inhibition of mouse mammary tumor progression.},
  author={Thuy Linh Phung and Godfred Eyiah-Mensah and R O'donnell and Radoslaw Bieniek and Sharon Shechter and Kenneth Walsh and Charlotte Kuperwasser and Laura E. Benjamin},
  journal={Cancer research},
  year={2007},
  volume={67 11},
  pages={5070-5}
}
Chronic activation of Akt signaling in the endothelium recapitulates the salient features of a tumor vasculature and can be inhibited by rapamycin, an inhibitor of mammalian target of rapamycin. This led to the hypothesis that the antitumor efficacy of rapamycin may be partially dependent on its ability to inhibit endothelial Akt signaling, making rapamycin an antiangiogenic agent and endothelial Akt pathway inhibitor. Dose-response studies with rapamycin showed that primary human endothelial… CONTINUE READING
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Endothelial Akt signaling is rate - limiting for rapamycin inhibition of mouse mammary tumor progression

  • TL Phung, G Eyiah-Mensah, +5 authors LE Benjamin
  • Cancer Res
  • 2007

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