Endothelial 12(S)-HETE vasorelaxation is mediated by thromboxane receptor inhibition in mouse mesenteric arteries.

@article{Siangjong2013Endothelial1V,
  title={Endothelial 12(S)-HETE vasorelaxation is mediated by thromboxane receptor inhibition in mouse mesenteric arteries.},
  author={Lawan Siangjong and Kathryn M. Gauthier and Sandra L. Pfister and Emer M. Smyth and William Campbell},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2013},
  volume={304 3},
  pages={
          H382-92
        }
}
Arachidonic acid (AA) metabolites mediate endothelium-dependent relaxation in many vascular beds. Previously, we identified the major AA 12/15-lipoxygenase (12/15-LO) metabolite of mouse arteries as 12-hydroxyeicosatetraenoic acid (12-HETE). The goal was to determine the stereospecific configuration of mouse vascular 12-HETE and characterize the role of 12-HETE stereoisomers in the regulation of vascular tone. Using normal, reverse phase, and chiral HPLC, the stereospecific configuration was… CONTINUE READING

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