Endothelial β4 integrin is predominantly expressed in arterioles, where it promotes vascular remodeling in the hypoxic brain.

@article{WelserAlves2013EndothelialI,
  title={Endothelial β4 integrin is predominantly expressed in arterioles, where it promotes vascular remodeling in the hypoxic brain.},
  author={Jennifer V. Welser-Alves and Amin Boroujerdi and Ulrich Tigges and Lawrence Wrabetz and Maria Laura Feltri and Richard S Milner},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2013},
  volume={33 5},
  pages={943-53}
}
OBJECTIVE Laminin is a major component of the vascular basal lamina, implying that laminin receptors, such as α6β1 and α6β4 integrins, may regulate vascular remodeling and homeostasis. Previous studies in the central nervous system have shown that β4 integrin is expressed by only a fraction of cerebral vessels, but defining the vessel type and cellular source of β4 integrin has proved controversial. The goal of this study was to define the class of vessel and cell type expressing β4 integrin in… CONTINUE READING
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