Endothelial‐Dependent Relaxation Induced by Leukotrienes C4, D4, and E4 in Isolated Canine Arteries

@article{Secrest1988EndothelialDependentRI,
  title={Endothelial‐Dependent Relaxation Induced by Leukotrienes C4, D4, and E4 in Isolated Canine Arteries},
  author={Roberta J. Secrest and Barry M. Chapnick},
  journal={Circulation Research},
  year={1988},
  volume={62},
  pages={983–991}
}
Leukotriene D4 has been shown to possess the capacity to relax canine superior mesenteric and renal arterial rings in an endothelial-dependent manner. The present study was designed to determine if the remaining peptidoleukotrienes, leukotrienes C4 and E4, share this property. In addition, influences of atropine and of inhibitors of cyclooxygenase and lipoxygenase activities on relaxation produced by leukotriene D4 and acetylcholine were determined to characterize further leukotriene D4-induced… Expand
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