Endosulfan-induced biochemical changes in the testis of rats.

  title={Endosulfan-induced biochemical changes in the testis of rats.},
  author={Neeraj Sinha and Ramamurthy Narayan and Ravi M. Shanker and Daya Krishna Saxena},
  journal={Veterinary and human toxicology},
  volume={37 6},
Adult male rats were exposed to 0, 2.5, 5.0 or 10.0 mg endosulfan/kg body weight through oral intubation for 70 d. Decreased sperm counts in the cauda epididymis and reduced intratesticular spermatid counts associated with elevation in the activities of specific testicular marker enzymes (sorbitol dehydrogenase, lactic dehydrogenase, gamma glutamyl transpeptidase, and glucose-6-phosphate dehydrogenase) were seen in all the endosulfan-dosed groups. Endosulfan caused impairment in testicular… CONTINUE READING


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