Endospanins regulate a postinternalization step of the leptin receptor endocytic pathway.

@article{Sron2011EndospaninsRA,
  title={Endospanins regulate a postinternalization step of the leptin receptor endocytic pathway.},
  author={Karin S{\'e}ron and Cyril Couturier and Sandrine Belouzard and Johan Bacart and Didier Mont{\'e} and Laetitia Corset and Olivier Bocquet and J J M Ten Dam and Virginie Vauthier and C{\'e}cile Lecœur and Bernard Bailleul and Bernard Hoflack and Philippe Froguel and Ralf Jockers and Yves Rouill{\'e}},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 20},
  pages={17968-81}
}
Endospanin-1 is a negative regulator of the cell surface expression of leptin receptor (OB-R), and endospanin-2 is a homologue of unknown function. We investigated the mechanism for endospanin-1 action in regulating OB-R cell surface expression. Here we show that endospanin-1 and -2 are small integral membrane proteins that localize in endosomes and the trans-Golgi network. Antibody uptake experiments showed that both endospanins are transported to the plasma membrane and then internalized into… CONTINUE READING

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Number 20 Journal of Biological Chemistry

T. Touvier, F. Conte-Auriol, +8 authors B. Bailleul
J. Clin. Invest. 119, • 2009

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