Endosome fusion and microtubule-based dynamics in the early endocytic pathway of dictyostelium.

@article{Clarke2002EndosomeFA,
  title={Endosome fusion and microtubule-based dynamics in the early endocytic pathway of dictyostelium.},
  author={Margaret Clarke and Jana Koehler and John M Heuser and G{\"u}nther Gerisch},
  journal={Traffic},
  year={2002},
  volume={3 11},
  pages={791-800}
}
Dictyostelium amoebae, like mammalian macrophages, take up fluid by macropinocytosis. The present study used fluorescent fluid-phase markers and GFP-labeled microtubules to visualize the uptake, dynamics, and fusion of early endosomes in Dictyostelium. Consecutive labeling with two fluorescent fluid-phase markers demonstrated that within the first few minutes after uptake, new macropinosomes underwent fusion with pre-existing endosomes. The fusing endosomes, which represent the mixing… CONTINUE READING
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