Endosomal translocation of CpG-oligodeoxynucleotides inhibits DNA-PKcs-dependent IL-10 production in macrophages.

@article{Yotsumoto2008EndosomalTO,
  title={Endosomal translocation of CpG-oligodeoxynucleotides inhibits DNA-PKcs-dependent IL-10 production in macrophages.},
  author={Satoshi Yotsumoto and Kazuharu Saegusa and Yukihiko Aramaki},
  journal={Journal of immunology},
  year={2008},
  volume={180 2},
  pages={
          809-16
        }
}
Synthetic oligodeoxynucleotides containing unmethylated CpG motifs (CpG-ODNs) function as powerful immune adjuvants by activating macrophages, dendritic cells, and B cells. However, the molecular recognition mechanism that initiates signaling in response to CpG-ODN has not fully been identified. We show in this study that peritoneal macrophages from SCID mice having mutations in the catalytic subunit of DNA-protein kinase (DNA-PKcs) were almost completely defective in the production of IL-10… CONTINUE READING

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