Endosomal sorting complex required for transport proteins in cancer pathogenesis, vesicular transport, and non-endosomal functions.

@article{Tanaka2008EndosomalSC,
  title={Endosomal sorting complex required for transport proteins in cancer pathogenesis, vesicular transport, and non-endosomal functions.},
  author={Nobuyuki Tanaka and Masanao Kyuuma and Kazuo Sugamura},
  journal={Cancer science},
  year={2008},
  volume={99 7},
  pages={1293-303}
}
Endosomal sorting complex required for transport (ESCRT) proteins form a multicomplex sorting machinery that controls multivesicular body (MVB) formation and the sorting of ubiquitinated membrane proteins to the endosomes. Being sorted to the MVB generally results in the lysosome-dependent degradation of cell-surface receptors, and defects in this machinery induce dysregulated receptor traffic and turnover. Recent lessons from gene targeting and silencing methodologies have implicated the ESCRT… CONTINUE READING