Endosomal chloride-proton exchange rather than chloride conductance is crucial for renal endocytosis.

@article{Novarino2010EndosomalCE,
  title={Endosomal chloride-proton exchange rather than chloride conductance is crucial for renal endocytosis.},
  author={Gaia Novarino and Stefanie Weinert and Gesa Rickheit and Thomas J Jentsch},
  journal={Science},
  year={2010},
  volume={328 5984},
  pages={1398-401}
}
Loss of the endosomal anion transport protein ClC-5 impairs renal endocytosis and underlies human Dent's disease. ClC-5 is thought to promote endocytosis by facilitating endosomal acidification through the neutralization of proton pump currents. However, ClC-5 is a 2 chloride (Cl-)/proton (H+) exchanger rather than a Cl- channel. We generated mice that carry the uncoupling E211A (unc) mutation that converts ClC-5 into a pure Cl- conductor. Adenosine triphosphate (ATP)-dependent acidification of… CONTINUE READING

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