Endosomal acidification and cathepsin L activity is required for calicivirus replication

@article{Shivanna2014EndosomalAA,
  title={Endosomal acidification and cathepsin L activity is required for calicivirus replication},
  author={Vinay Shivanna and Y. Kim and Kyeong-Ok Chang},
  journal={Virology},
  year={2014},
  volume={464},
  pages={287 - 295}
}
Abstract The role of cellular proteases and endosome maturation in the entry of caliciviruses including porcine enteric calicivirus (PEC), murine norovirus (MNV)-1 and feline calicivirus (FCV) were investigated. Treatment with chloroquine or cathepsin L inhibitors, but not cathepsin B inhibitors, significantly reduced the replication of PEC, MNV and FCV. When concentrated PEC, MNV or FCV were incubated with recombinant cathepsin L, the minor capsid protein VP2 of PEC and the major capsid… Expand
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