Endosidin2 targets conserved exocyst complex subunit EXO70 to inhibit exocytosis.

  title={Endosidin2 targets conserved exocyst complex subunit EXO70 to inhibit exocytosis.},
  author={Chunhua Zhang and Michelle Q Brown and Wilhelmina T G van de Ven and Zhi-Min Zhang and Bin Wu and Michael C Young and Luk{\'a}{\vs} Synek and Dan B Borchardt and Reed E. S. Harrison and Songqin Pan and Nan Luo and Yu-ming M. Huang and Yoo-Jin Ghang and Nolan Ung and Ruixi Li and Jonathan Isley and Dimitrios Morikis and Jikui Song and Wei Guo and Richard J Hooley and Chia-en A. Chang and Zhenbiao Yang and Viktor Ž{\'a}rsk{\'y} and Gloria K. Muday and Glenn R Hicks and Natasha V. Raikhel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={113 1},
The exocyst complex regulates the last steps of exocytosis, which is essential to organisms across kingdoms. In humans, its dysfunction is correlated with several significant diseases, such as diabetes and cancer progression. Investigation of the dynamic regulation of the evolutionarily conserved exocyst-related processes using mutants in genetically tractable organisms such as Arabidopsis thaliana is limited by the lethality or the severity of phenotypes. We discovered that the small molecule… CONTINUE READING
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