Endoscopic photoconversion reveals unexpectedly broad leukocyte trafficking to and from the gut.

@article{Morton2014EndoscopicPR,
  title={Endoscopic photoconversion reveals unexpectedly broad leukocyte trafficking to and from the gut.},
  author={Angela M Y Morton and Esen Sefik and Rabi Upadhyay and Ralph Weissleder and Christophe Benoist and Diane Mathis},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 18},
  pages={6696-701}
}
Given mounting evidence of the importance of gut-microbiota/immune-cell interactions in immune homeostasis and responsiveness, surprisingly little is known about leukocyte movements to, and especially from, the gut. We address this topic in a minimally perturbant manner using Kaede transgenic mice, which universally express a photoconvertible fluorescent reporter. Transcutaneous exposure of the cervical lymph nodes to violet light permitted punctual tagging of immune cells specifically therein… CONTINUE READING

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Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX(3)CR1(hi) cells

  • GE Diehl
  • Nature
  • 2013
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