Endoscopic delivery of enteric neural stem cells to treat Hirschsprung disease

@article{Cheng2015EndoscopicDO,
  title={Endoscopic delivery of enteric neural stem cells to treat Hirschsprung disease},
  author={L S Cheng and Ryo Hotta and Hannah K Graham and N{\'a}ndor Nagy and Allan M. Goldstein and Jaime Belkind-Gerson},
  journal={Neurogastroenterology \& Motility},
  year={2015},
  volume={27}
}
Transplantation of enteric neural stem cells (ENSC) holds promise as a potential therapy for enteric neuropathies, including Hirschsprung disease. Delivery of transplantable cells via laparotomy has been described, but we propose a novel, minimally invasive endoscopic method of cell delivery. 
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Recent in vivo transplantation studies have confirmed that ENSCs are capable of engraftment within recipient intestine of animal models of enteric neuropathy and effecting functional rescue, and pluripotent stem cell‐derived cells and pharmacological modulation of both endogenous and transplanted neural stem cells have further enhanced the exciting prospect of clinical application of such stem cell-based therapies in the near future.
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TLDR
Recent advances in animal models of HSCR are summarized and opportunities for new discoveries in this field are highlighted.
Exposure to GDNF Enhances the Ability of Enteric Neural Progenitors to Generate an Enteric Nervous System
TLDR
The data show that the ability of enteric neurospheres to generate an ENS can be enhanced by exposure to appropriate factors.
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