• Medicine
  • Published in The Journal of rheumatology 2001

Endorphin and enkephalin ameliorate excessive synovial cell functions in patients with rheumatoid arthritis.

@article{Takeba2001EndorphinAE,
  title={Endorphin and enkephalin ameliorate excessive synovial cell functions in patients with rheumatoid arthritis.},
  author={Yuko Takeba and Noboru Suzuki and Azusa Kaneko and Tohru Asai and Tsuyoshi Sakane},
  journal={The Journal of rheumatology},
  year={2001},
  volume={28 10},
  pages={
          2176-83
        }
}
OBJECTIVE To determine whether endorphin (END) and enkephalin (ENK) modulate excessive synovial cell functions in patients with rheumatoid arthritis (RA). METHODS Effects of leucine-enkephalin (leu-ENK), methionine-enkephalin (met-ENK), and beta-endorphin (END) on proinflammatory cytokine and matrix metalloproteinase (MMP) production by RA synovial cells were analyzed by immunoblotting, and their mRNA expression by reverse transcription-polymerase chain reaction (RT-PCR) using limiting… CONTINUE READING

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