Endoribonuclease type II toxin-antitoxin systems: functional or selfish?

@article{Ramisetty2017EndoribonucleaseTI,
  title={Endoribonuclease type II toxin-antitoxin systems: functional or selfish?},
  author={Bhaskar Chandra Mohan Ramisetty and Ramachandran Sarojini Santhosh},
  journal={Microbiology},
  year={2017},
  volume={163 7},
  pages={
          931-939
        }
}
Most bacterial genomes have multiple type II toxin-antitoxin systems (TAs) that encode two proteins which are referred to as a toxin and an antitoxin. Toxins inhibit a cellular process, while the interaction of the antitoxin with the toxin attenuates the toxin's activity. Endoribonuclease-encoding TAs cleave RNA in a sequence-dependent fashion, resulting in translational inhibition. To account for their prevalence and retention by bacterial genomes, TAs are credited with clinically significant… Expand
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  • C. Yeo
  • Biology, Medicine
  • Molecular microbiology
  • 2018
TLDR
A unique GNAT‐RHH TA system, designated KacAT, is described from a multidrug resistant strain of the pathogen, Klebsiella pneumoniae, which expands knowledge on this newly discovered family of TA toxins and the potential role that they may play in antibiotic tolerance and persistence of bacterial pathogens. Expand
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TLDR
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