Endoribonuclease type II toxin-antitoxin systems: functional or selfish?

  title={Endoribonuclease type II toxin-antitoxin systems: functional or selfish?},
  author={B. C. M. Ramisetty and R. S. Santhosh},
  volume={163 7},
  • B. C. M. Ramisetty, R. S. Santhosh
  • Published 2017
  • Biology, Medicine
  • Microbiology
  • Most bacterial genomes have multiple type II toxin-antitoxin systems (TAs) that encode two proteins which are referred to as a toxin and an antitoxin. Toxins inhibit a cellular process, while the interaction of the antitoxin with the toxin attenuates the toxin's activity. Endoribonuclease-encoding TAs cleave RNA in a sequence-dependent fashion, resulting in translational inhibition. To account for their prevalence and retention by bacterial genomes, TAs are credited with clinically significant… CONTINUE READING
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