Endoribonuclease type II toxin-antitoxin systems: functional or selfish?

@article{Ramisetty2017EndoribonucleaseTI,
  title={Endoribonuclease type II toxin-antitoxin systems: functional or selfish?},
  author={B. C. M. Ramisetty and R. S. Santhosh},
  journal={Microbiology},
  year={2017},
  volume={163 7},
  pages={
          931-939
        }
}
  • B. C. M. Ramisetty, R. S. Santhosh
  • Published 2017
  • Biology, Medicine
  • Microbiology
  • Most bacterial genomes have multiple type II toxin-antitoxin systems (TAs) that encode two proteins which are referred to as a toxin and an antitoxin. Toxins inhibit a cellular process, while the interaction of the antitoxin with the toxin attenuates the toxin's activity. Endoribonuclease-encoding TAs cleave RNA in a sequence-dependent fashion, resulting in translational inhibition. To account for their prevalence and retention by bacterial genomes, TAs are credited with clinically significant… CONTINUE READING
    21 Citations
    Regulation of Type II Toxin-Antitoxin Systems: The Translation-Responsive Model
    • 1
    • PDF
    Type II Toxin-Antitoxin Systems: Evolution and Revolutions
    • 21
    • PDF
    GNAT toxins of bacterial toxin–antitoxin systems: acetylation of charged tRNAs to inhibit translation
    • C. C. Yeo
    • Biology, Medicine
    • Molecular microbiology
    • 2018
    • 12

    References

    SHOWING 1-10 OF 95 REFERENCES
    Chromosomal toxin-antitoxin systems may act as antiaddiction modules.
    • 104
    • Highly Influential
    • PDF
    Bacterial toxin-antitoxin systems: more than selfish entities?
    • 209
    One cannot rule them all: Are bacterial toxins-antitoxins druggable?
    • 52
    • PDF
    Toxin-Antitoxin Systems as Multilevel Interaction Systems
    • 164
    • PDF
    Horizontal gene transfer of chromosomal Type II toxin-antitoxin systems of Escherichia coli.
    • 40
    • PDF
    mazEF-mediated programmed cell death in bacteria: “What is this?”
    • 39